|
KMID : 1812020190250010100
|
|
Journal of Neurogastroenterology and Motility
2019 Volume.25 No. 1 p.100 ~ p.112
|
|
|
Propagation Characteristics of Fasting Duodeno-Jejunal Contractions in Healthy Controls Measured by Clustered Closely-spaced Manometric Sensors
|
|
|
|
|
Abstract
|
|
|
Background/Aims: High-resolution methods have advanced esophageal and anorectal manometry interpretation but are incompletely established for intestinal manometry. We characterized normal fasting duodeno-jejunal manometry parameters not measurable by standard techniques using clustered closely-spaced recordings.
Methods: Ten fasting recordings were performed in 8 healthy controls using catheters with 3?4 gastrointestinal manometry clusters with 1?2 cm channel spacing. Migrating motor complex phase III characteristics were quantified. Spatial-temporal contour plots measured propagation direction and velocity of individual contractions. Coupling was defined by pressure peak continuity within clusters.
Results: Twenty-three phase III complexes (11 antral, 12 intestinal origin) with 157 (95% CI, 104?211) minute periodicities, 6.99 (6.25?7.74) minute durations, 10.92 (10.68?11.16) cycle/minute frequencies, 73.6 (67.7?79.5) mmHg maximal amplitudes, and 4.20 (3.18?5.22) cm/minute propagation velocities were recorded. Coupling of individual contractions was 39.1% (32.1?46.1); 63.0% (54.4?71.6) of contractions were antegrade and 32.8% (24.1?41.5) were retrograde. Individual phase III contractions propagated > 35 fold faster (2.48 cm/sec; 95% CI, 2.25?2.71) than complexes themselves. Phase III complexes beyond the proximal jejunum were longer in duration (P = 0.025) and had poorer contractile coupling (P = 0.025) than proximal complexes. Coupling was greater with 1 cm channel spacing vs 2 cm (P < 0.001).
Conclusions: Intestinal manometry using clustered closely-spaced pressure ports characterizes novel antegrade and retrograde propagation and coupling properties which degrade in more distal jejunal segments. Coupling is greater with more closely-spaced recordings. Applying similar methods to dysmotility syndromes will define the relevance of these methods.
|
|
|
KEYWORD
|
|
|
Intestines, Manometry, Migrating, Muscle contraction, Myoelectric complex
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
   
|
|